Yet another vector being exploited by miscreants is the APT28 rootkit which accesses your firmware BIOS settings/ UEFI. There is no known check for this and re-flashing your firmware/ UEFI or replacing your motherboard seems the only way to eradicate the rootkit!
Security researchers tracking the operations of a cyber-espionage group found the first evidence of a rootkit for the Unified Extensible Firmware Interface (UEFI) being used in the wild.
The threat actor, known in the infosec community by the names Sednit, Fancy Bear, APT28, Strontium, and Sofacy, was able to write a malicious component into a machine’s UEFI firmware.
More info over at bleepingcomputer with advice on a defending against this.