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I have used UBCD4win (UBCD4win.com) quite successfully, as it includes several anti-spyware and antivirus programs that can be run with a single boot. Various versions of this utility have included different anti-malware programs. A very useful feature is the ability to add programs of your choice to the options, although this might not be a preferred option for the technologically faint of heart.

I have also removed the suspect hard disk from the infected computer and scanned it on other systems that have different anti-malware programs installed (typically using a USB or eSATA hard disk dock). This utility can be installed on either a bootable DVD or USB stick.

Regardless, I have always made a full image backup of the infected disk prior to scanning, lest an over-enthusiastic scan resulted in removing an essential file or setting.

Have you ever considered using DVD-RAM disks. While more expensive than DVD-RW, they can be written many more times and can be used in the same way as hard disks.

https://en.wikipedia.org/wiki/DVD-RAM

Bill

I agree with the suggestions to remove System Restore points to prevent re-infection. In my business, the first thing I do with a customer’s computer is make an image backup of their hard disk. I can then delete restore points, temporary files, and malware – confident that if anything critical is removed by me or an overly aggressive anti-malware program it can be restored.