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You should maybe clean up the registry.
Then I think Security Center will know that Norton is uninstalled.

Edited by HansV to reduce screenshot in size – please don’t post pictures larger than 640×480

Looking at the shutdown message, since this is in Windowssystem32,it would be a Windows system file.
Edit:I have a picture showing that I also have it.
Note that I have info, it says Microsoft Corporation, so it shouldn’t be harmful.

I encountered this and I thought that I should reboot.
So I rebooted and that did the trick.
Rebooting normally works.

Is your taskbar high enough to see it?

I had that same problem most of the time.
But not all the time, luckily.

When I lose a program from the taskbar, I always hit Alt+Tab to the one that I lost from the taskbar.

Well, for programs not in use,you can safely delete the files.
BUT:Not all will delete. Try closing some programs first then delete them.

I would leave it alone and not poking it with a sharp stick.
Besides,Windows Defender is an anti-spyware program.

That is just a change in the Windows system DLLs.
It may be good or bad.